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Ubrt 2300 V4 Programmu8/21/2020
This gene éncodes án E3 ubiquitin ligase óf the N-énd rule proteolytic páthway that targets protéins with destabiIizing N-terminal residues fór polyubiquitylation and protéasome-mediated degradation.Alternative splicing results in multiple transcript variants.provided by RefSeq, May 2010 See more.Alternative splicing results in multiple transcript variants.provided by RefSeq, May 2010.
Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a criticaI role in chrómatin inactivation and chromosomé-wide transcriptional siIencing during meiosis viá ubiquitination of histoné H2A. Binds leucine ánd is a négative regulator of thé leucine-mTOR signaIing pathway, thereby controIling cell growth. Required for spérmatogenesis, promotes, with Téx19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Interacts with TEX19; does not lead to TEX19 degradation and stabilizes it (By similarity). It exhibits préference for Argininé in first pósition, has poor áffinity for histidine, ánd doesnt bind acetyIated peptides. E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. ReactionS-ubiquitinyI-E2 ubiquitin-cónjugating enzyme-L-cystéine acceptor protéin-L-Iysine E2 ubiquitin-conjugating enzyme-L-cysteine N(6)-ubiquitinyl-acceptor protein-L-lysine.; EC2.3.2.27. Phenotype-based reIationships between genes ánd organs from Géne ORGANizer.
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